The GABBR1 Polyclonal Antibody (CAB10504) is a valuable tool for researchers studying the GABBR1 protein, a key component of the GABAB receptor complex involved in neurotransmission. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the GABBR1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential tool for investigations in neuroscience and pharmacology.The GABBR1 protein plays a crucial role in mediating inhibitory neurotransmission in the central nervous system, impacting functions such as synaptic plasticity, neuronal excitability, and cognitive processes.
Dysfunction of the GABAB receptor system has been implicated in various neurological and psychiatric disorders, highlighting the importance of studying the GABBR1 protein for therapeutic development.Researchers exploring conditions such as epilepsy, addiction, anxiety, and schizophrenia can benefit from utilizing the GABBR1 Polyclonal Antibody to investigate the molecular mechanisms underlying these disorders. By gaining insights into the role of the GABBR1 protein, scientists can advance the development of novel treatment strategies targeting the GABAB receptor complex.
Product Name:
GABBR1 Rabbit Polyclonal Antibody
SKU:
CAB10504
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-460 of human GABBR1 (NP_068703.1).
This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA(B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
2550
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GABBR1 antibody (CAB10504) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
