The Gabarap Polyclonal Antibody (CAB13855) is a valuable tool for researchers studying Gabarap, a cellular protein involved in autophagy, the body's natural process for disposing of damaged or unnecessary cellular components. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications. By binding specifically to Gabarap, this antibody enables researchers to detect and analyze the protein in various cell types, providing insights into its role in autophagy and potential implications in diseases such as cancer, neurodegenerative disorders, and metabolic conditions.
Gabarap, short for GABA(A) receptor-associated protein, is a key player in the autophagy pathway, helping to transport cellular cargo to the lysosome for degradation. Dysregulation of autophagy has been linked to a range of diseases, making Gabarap an attractive target for research in understanding the underlying mechanisms and developing therapeutic interventions. By studying the activity and regulation of Gabarap, researchers can uncover new avenues for therapeutic development and better grasp the role of autophagy in maintaining cellular health.
Product Name:
GABARAP Rabbit Polyclonal Antibody
SKU:
CAB13855
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GABARAP (NP_009209.1).
Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.
Purification Method:
Affinity purification
Gene ID:
11337
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GABARAP antibody (CAB13855) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 40s.
