The Gab1 Monoclonal Antibody is a valuable tool for researchers studying the Gab1 protein, a key regulator of cell signaling pathways involved in growth, survival, and differentiation. This antibody, generated from mouse hybridoma cells, offers high specificity and sensitivity for detecting Gab1 in various cell types and tissues. It is validated for use in techniques such as Western blotting and immunofluorescence, enabling detailed analysis of Gab1 expression and localization.Gab1, a scaffolding/adaptor protein, is known to interact with multiple signaling molecules, including receptor tyrosine kinases and intracellular kinases, to transduce extracellular signals into intracellular responses. Dysregulation of Gab1 signaling has been implicated in various diseases, including cancer, cardiovascular disorders, and developmental abnormalities.
Research into the function of Gab1 can provide insights into these pathological conditions and potentially lead to the development of therapeutic interventions targeting Gab1-dependent pathways.Overall, the Gab1 Monoclonal Antibody serves as a valuable tool for investigating the role of Gab1 in cellular signaling pathways and its implications for disease pathogenesis. Its high specificity and reliability make it a trusted reagent for immunology, oncology, and cell biology studies, contributing to advancements in our understanding of Gab1 function and its potential as a therapeutic target.
Product Name:
GAB1 Monoclonal Antibody
SKU:
CAB23499
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant protein of human GAB1.
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:1000
Synonyms:
DFNB26; GAB1
Positive Sample:
293T,HepG2,Mouse lung
Conjugate:
Unconjugated
Calculated MW:
76kDa/80kDa
Observed MW:
110kDa
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2549
Clone Number:
ARC52035
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of Mouse lung, using GAB1 Rabbit mAb (CAB23499) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
