The G6PD Rabbit Monoclonal Antibody is a powerful tool for researchers studying the G6PD enzyme, which plays a crucial role in the pentose phosphate pathway and redox regulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting G6PD in human samples, making it a reliable choice for Western blot applications.G6PD deficiency is a common enzymatic disorder that can lead to hemolytic anemia under certain conditions. Research into G6PD function and regulation is important for understanding the pathophysiology of this disorder and developing potential treatments.
The G6PD Rabbit Monoclonal Antibody enables precise detection and analysis of G6PD levels in various cell types, aiding in studies related to metabolism, oxidative stress, and redox signaling pathways. With its ability to specifically target G6PD, this antibody is a valuable tool for researchers investigating metabolic disorders, oxidative stress-related diseases, and potential therapeutic interventions targeting the pentose phosphate pathway. Its reliability and sensitivity make it an essential component of studies in biochemistry, molecular biology, and drug development.
Product Name:
G6PD Rabbit Monoclonal Antibody
SKU:
CAB11234
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human G6PD (P11413).
Cytoplasm, Cytoplasmic side of plasma membrane, cytosol, Extracellular exosome, Nucleus
Calculated MW:
59kDa
Observed MW:
59kDa
This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2539
Clone Number:
ARC0553
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using G6PD Rabbit mAb (CAB11234) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
