The G3BP Rabbit Monoclonal Antibody (CAB3968) is a valuable tool for researchers studying G3BP, a protein involved in stress granule formation and RNA metabolism. This antibody, produced using rabbit monoclonal technology, exhibits high reactivity with human samples and is validated for use in immunofluorescence and immunohistochemistry applications. By specifically binding to G3BP, researchers can detect and analyze its expression in various cell types, making it an ideal choice for studies in cellular stress response and RNA regulation.G3BP is known to play a crucial role in cellular stress response pathways, including responses to viral infections, oxidative stress, and heat shock.
Its involvement in stress granule formation and regulation of RNA metabolism makes it a key player in cellular homeostasis and adaptation to environmental stresses. Research on G3BP is particularly relevant in the fields of virology, cancer biology, and neurodegenerative diseases, where disruptions in stress response pathways can have significant implications for disease progression and treatment. By using the G3BP Rabbit Monoclonal Antibody (CAB3968), researchers can delve deeper into the mechanisms underlying cellular stress responses and RNA regulation, contributing to advancements in various fields of biomedical research.
Product Name:
G3BP1 Rabbit Monoclonal Antibody
SKU:
CAB3968
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human G3BP1 (Q13283).
This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
10146
Clone Number:
ARC0875
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using G3BP1 Rabbit mAb (CAB3968) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
