The FZD8 Polyclonal Antibody (CAB18393) is a versatile tool for researchers studying the FZD8 protein, a key component of the Wnt signaling pathway involved in cell proliferation, differentiation, and migration. This rabbit-derived antibody is highly specific to human samples and has been validated for use in Western blot applications, enabling accurate detection and analysis of FZD8 in various cell types.FZD8, a member of the Frizzled family of proteins, plays a crucial role in embryonic development and tissue homeostasis, making it a target of interest in cancer research and regenerative medicine.
By targeting FZD8, researchers can better understand its impact on cell behavior and potentially develop novel therapeutic strategies for treating diseases characterized by dysregulated Wnt signaling.With its high reactivity and specificity, the FZD8 Polyclonal Antibody (CAB18393) is an essential tool for investigating the role of FZD8 in cellular processes and disease pathogenesis. Its application in immunology and cancer research offers new insights into the mechanisms underlying Wnt signaling and opens up opportunities for the development of targeted therapies.
Product Name:
FZD8 Rabbit Polyclonal Antibody
SKU:
CAB18393
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 130-275 of human FZD8 (NP_114072.1).
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
Purification Method:
Affinity purification
Gene ID:
8325
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FZD8 Rabbit pAb (CAB18393) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
