The FZD4 Polyclonal Antibody (CAB8161) is a valuable tool for researchers studying the FZD4 protein, a receptor involved in the Wnt signaling pathway, which plays a crucial role in various cellular processes including development, tissue regeneration, and cancer progression. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blotting applications.FZD4 is a key player in the Wnt signaling pathway, which is known to be dysregulated in many diseases, particularly cancer. By specifically binding to the FZD4 protein, this antibody allows for the detection and analysis of FZD4 expression in different cell types, making it an ideal choice for studies in developmental biology, tissue regeneration, and cancer research.
Understanding the function of FZD4 and its involvement in signaling pathways is crucial for unraveling its role in disease pathogenesis and potentially identifying new therapeutic targets. The FZD4 Polyclonal Antibody (CAB8161) offers researchers a reliable tool to further investigate the biological functions of FZD4 and its implications in various disease conditions.
Product Name:
FZD4 Rabbit Polyclonal Antibody
SKU:
CAB8161
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 42-179 of human FZD4 (NP_036325.2).
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.
Purification Method:
Affinity purification
Gene ID:
8322
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using FZD4 Rabbit pAb (CAB8161) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
