The FYCO1 Polyclonal Antibody (PAC040710) is a valuable tool for researchers studying FYCO1, a protein involved in autophagy and cellular trafficking processes. This high-quality antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to FYCO1, the antibody allows for the detection and analysis of this important protein in various cell types, making it essential for studies in cell biology and neurodegenerative diseases.FYCO1 plays a crucial role in the autophagy pathway, specifically in the recruitment of autophagosomes to microtubule plus ends.
Dysregulation of FYCO1 has been implicated in various diseases, including neurodegenerative disorders and cancer. By understanding the function of FYCO1, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.Overall, the FYCO1 Polyclonal Antibody is a reliable tool for researchers looking to investigate the role of FYCO1 in cellular processes and disease pathogenesis. Its specificity and sensitivity make it an ideal choice for studies aiming to elucidate the functions of FYCO1 in health and disease.
Western blot. All lanes: FYCO1 antibody at 2.5µg/ml. Lane 1: HepG2 whole cell lysate. Lane 2: Mouse liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 167, 44, 169 kDa. Observed band size: 167 kDa.
Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO40710 at dilution of 1:100.
Background:
May mediate microtubule plus end-directed vesicle transport.
Synonyms:
FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7), FYCO1, ZFYVE7
UniProt Protein Function:
FYCO1: May mediate microtubule plus end-directed vesicle transport. Defects in FYCO1 are the cause of cataract congenital autosomal recessive type 2 (CATC2). An opacification of the crystalline lens of the eye becoming evident at birth or in infancy. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (PubMed:21636066). 3 isoforms of the human protein are produced by alternative splicing.Protein type: AutophagyChromosomal Location of Human Ortholog: 3p21.31Cellular Component: autophagic vacuole; cytoplasmic vesicle; integral to membrane; intracellular membrane-bound organelle; late endosome; lysosome; membraneMolecular Function: metal ion binding; protein bindingDisease: Cataract 18
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011]
