The FXYD4 Monoclonal Antibody (PACO09370) is a valuable tool for researchers studying the FXYD4 protein, a regulatory subunit of the Na,K-ATPase pump. This antibody, generated in mice, exhibits high specificity and sensitivity towards human samples, making it suitable for use in various experimental techniques, including Western blot and immunofluorescence.FXYD4 is a crucial component in the regulation of ion transport processes, particularly in maintaining ion balance across cell membranes. Dysregulation of FXYD4 has been linked to various diseases, including hypertension, heart failure, and renal disorders.
Therefore, understanding the function and expression of FXYD4 is essential for uncovering its role in these pathologies and developing potential therapeutic interventions.With its ability to target the FXYD4 protein specifically, the PACO09370 Monoclonal Antibody enables researchers to visualize and quantify FXYD4 expression in different cell types and tissues. This antibody is a valuable asset for studies in physiology, cardiology, and nephrology, providing insights into the mechanisms of ion transport and their impact on health and disease.
FXYD domain containing ion transport regulator 4;FXYD4;CHIF ;
UniProt Protein Function:
FXYD4: a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, May 2010]Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 10q11.21Cellular Component: integral to membrane; plasma membraneMolecular Function: potassium channel activity; ATPase bindingBiological Process: transmembrane transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, May 2010]
