The FXR2 Polyclonal Antibody (CAB4313) is a valuable tool for researchers investigating FXR2, a member of the Fragile X family of proteins known for their roles in RNA metabolism and synaptic plasticity. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the FXR2 protein, researchers can accurately detect and analyze FXR2 expression in various cell types, making it an essential tool for studies in neuroscience, developmental biology, and genetic disorders.
FXR2 is a key player in regulating mRNA translation and protein synthesis, impacting processes crucial for neuronal development and function. Dysregulation of FXR2 has been associated with neurodevelopmental disorders such as Fragile X syndrome and autism spectrum disorders, underscoring its importance in understanding brain development and function. By studying FXR2 activity, researchers can gain insights into the mechanisms underlying these disorders and potentially identify new therapeutic targets for neurological conditions.
Product Name:
FXR2 Rabbit Polyclonal Antibody
SKU:
CAB4313
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 550-650 of human FXR2 (NP_004851.2).
The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X cognitive disability syndrome.
Purification Method:
Affinity purification
Gene ID:
9513
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using FXR2 Rabbit pAb (CAB4313) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
