The FXN Polyclonal Antibody (CAB1745) is a valuable tool for researchers studying frataxin, a protein involved in mitochondrial function and iron-sulfur cluster biogenesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the FXN protein, this antibody allows for the detection and analysis of frataxin in various cell types, making it ideal for investigations in the fields of bioenergetics and neurodegenerative diseases.
Frataxin plays a crucial role in cellular energy production and iron metabolism, making it a key player in neurological disorders such as Friedreich's Ataxia. The study of frataxin using the FXN Polyclonal Antibody can provide valuable insights into the mechanisms underlying these diseases and may lead to the development of targeted therapies. Researchers interested in mitochondrial function, iron homeostasis, and neurodegeneration will find this antibody to be an indispensable tool in their studies.
Product Name:
FXN/Frataxin Rabbit Polyclonal Antibody
SKU:
CAB1745
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 42-210 of human FXN / Frataxin (NP_000135.2).
This nuclear gene encodes a mitochondrial protein which belongs to the FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA from 8-33 repeats to >90 repeats results in Friedreich ataxia. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2395
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FXN / Frataxin Rabbit pAb (CAB1745) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
