The FXN Polyclonal Antibody (CAB16688) is a valuable tool for researchers studying frataxin, a protein involved in the regulation of iron-sulfur cluster biogenesis and mitochondrial function. The antibody, produced in rabbits, demonstrates strong reactivity with human samples and is suitable for Western blot applications. By specifically binding to the FXN protein, this antibody facilitates the analysis and detection of frataxin in various cell types, making it an essential component for investigations in mitochondrial biology and neurodegenerative diseases.Frataxin is known for its crucial role in maintaining mitochondrial health and energy production, making it a key player in cellular metabolism and oxidative stress response.
Dysregulation of frataxin has been linked to diseases such as Friedreich's ataxia, a progressive neurodegenerative disorder with no cure. Research into the function and regulation of frataxin is essential for developing targeted therapies for mitochondrial disorders and understanding the mechanisms underlying neurodegeneration.Overall, the FXN Polyclonal Antibody (CAB16688) offers researchers a reliable tool for studying frataxin and its implications in mitochondrial function and disease pathology. Its high specificity and sensitivity make it a valuable asset for advancing research in the field of mitochondrial biology and neurological disorders.
This nuclear gene encodes a mitochondrial protein which belongs to the FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA from 8-33 repeats to >90 repeats results in Friedreich ataxia. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2395
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FXN / Frataxin Rabbit pAb (CAB16688) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
