The FXN Polyclonal Antibody (CAB11785) is an essential tool for researchers studying frataxin, a key protein involved in the regulation of mitochondrial function and iron metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the FXN protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in the fields of mitochondrial biology and neurodegenerative diseases.Frataxin is a critical protein that plays a pivotal role in maintaining mitochondrial health and preventing oxidative damage.
Dysregulation of frataxin has been implicated in the pathogenesis of disorders such as Friedreich's ataxia, a progressive neurodegenerative disease. Research on frataxin has important implications for understanding mitochondrial dysfunction and developing therapeutic strategies for related conditions.Overall, the FXN Polyclonal Antibody serves as a valuable tool for researchers aiming to unravel the complex roles of frataxin in health and disease. Its high specificity and sensitivity make it a reliable choice for studies investigating mitochondrial function and exploring potential therapeutic interventions for frataxin-related disorders.
Product Name:
FXN/Frataxin Rabbit Polyclonal Antibody
SKU:
CAB11785
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 42-210 of human FXN / Frataxin (NP_000135.2).
This nuclear gene encodes a mitochondrial protein which belongs to the FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA from 8-33 repeats to >90 repeats results in Friedreich ataxia. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2395
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using FXN / Frataxin Rabbit pAb (CAB11785) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
