The FXN (Frataxin) Polyclonal Antibody is a valuable tool for researchers studying the role of frataxin in various cellular processes. Frataxin is a mitochondrial protein involved in iron-sulfur cluster biogenesis, making it essential for cellular function and energy production. This antibody, raised in rabbits, is highly specific to human frataxin and is ideal for use in Western blot applications. By binding to frataxin, researchers can easily detect and analyze its expression levels in different cell types, providing insights into its role in mitochondrial function and iron metabolism.
Research on frataxin is crucial for understanding diseases like Friedreich's ataxia, a neurodegenerative disorder caused by frataxin deficiency. This antibody can help uncover new insights into the mechanisms underlying this disease and potentially inform the development of therapeutic strategies targeting frataxin. Overall, the FXN (Frataxin) Polyclonal Antibody is a valuable tool for researchers investigating mitochondrial function, iron metabolism, and related diseases, offering high specificity and sensitivity for the study of frataxin in various research contexts.
Product Name:
FXN / Frataxin Polyclonal Antibody
SKU:
CAB21423
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 42-210 of human FXN / Frataxin (NP_000135.2).
This nuclear gene encodes a mitochondrial protein which belongs to the FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA from 8-33 repeats to >90 repeats results in Friedreich ataxia. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2395
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FXN / Frataxin Rabbit pAb (CAB21423) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
