The FUZ Antibody is a highly specific polyclonal antibody designed for research involving FUZ, a protein involved in regulating cell growth and development. This antibody, raised in rabbits, is validated for use in immunofluorescence and immunohistochemistry applications, allowing for precise detection and visualization of FUZ in various cell types.FUZ is a key player in the regulation of cellular processes such as cell proliferation, differentiation, and migration. Its involvement in these fundamental processes makes it a crucial target for research in developmental biology, cancer biology, and neurobiology.
By understanding the function and localization of FUZ, researchers can gain valuable insights into its role in disease progression and potential therapeutic strategies.The FUZ Antibody from AssayGenie provides researchers with a reliable tool for studying the function and localization of FUZ in their experimental models. With its high reactivity and specificity for human samples, this antibody is an essential resource for studies aiming to elucidate the complex mechanisms underlying cellular growth and development.
Immunohistochemistry analysis of human melanoma using PACO49314 at dilution of 1:100.
Immunofluorescent analysis of A549 cells using PACO49314 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity).
Synonyms:
Protein fuzzy homolog, FUZ, FY
UniProt Protein Function:
FUZ: Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. May regulate the morphogenesis of hair follicles which depends on functional primary cilia. Belongs to the fuzzy family. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 19q13.33Cellular Component: cytoskeleton; cytoplasmBiological Process: spinal cord dorsal/ventral patterning; embryonic skeletal morphogenesis; negative regulation of cell proliferation; embryonic body morphogenesis; protein transport; hair follicle development; sensory cilium biogenesis; neural tube closure; cilium biogenesis; establishment of planar polarity; negative regulation of cell migration; positive regulation of flagellum biogenesis; regulation of smoothened signaling pathwayDisease: Neural Tube Defects
UniProt Protein Details:
NCBI Summary:
This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associated with neural tube defects in humans. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]
