The FUT6 Polyclonal Antibody (CAB3868) is a valuable tool for researchers studying FUT6, a key enzyme involved in the biosynthesis of fucosylated glycoproteins and glycolipids. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By binding to the FUT6 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in glycobiology and cancer research.FUT6, a fucosyltransferase enzyme, plays a critical role in the modification of glycoproteins and glycolipids with fucose residues, which are essential for various cellular processes such as cell-cell interactions, signaling, and immune response regulation.
Dysregulation of FUT6 activity has been linked to a range of diseases including cancer, inflammatory disorders, and autoimmune conditions. By elucidating the role of FUT6 in these pathological processes, researchers can gain insights that may lead to the development of novel therapeutic strategies targeting fucosylation pathways.
Product Name:
FUT6 Rabbit Polyclonal Antibody
SKU:
CAB3868
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 170-359 of human FUT6 (NP_000141.1).
Golgi apparatus, Golgi stack membrane, Single-pass type II membrane protein.
Calculated MW:
42kDa
Observed MW:
42kDa
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2528
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from SW480 cells, using FUT6 Rabbit pAb (CAB3868) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
