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Furin Rabbit Monoclonal Antibody (CAB5043)

SKU:
CAB5043
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
FUR
PACE
PCSK3
SPC1
  • Immunology Antibodies 3 Anti-Furin Antibody CAB5043
  • Immunology Antibodies 3 Anti-Furin Antibody CAB5043
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Furin Rabbit Monoclonal Antibody
SKU:CAB5043
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Furin (P09958).
Sequence:GEVA AVAN NGVC GVGV AYNA RIGG VRML DGEV TDAV EARS LGLN PNHI HIYS ASWG PEDD GKTV DGPA RLAE EAFF RGVS QGRG GLGS IFVW ASGN GGRE H
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:FUR; PACE; SPC1; PCSK3; Furin
Positive Sample:HeLa,HT-29,A-549,Mouse brain
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Golgi apparatus, Single-pass type I membrane protein, trans-Golgi network membrane, Secreted, Endosome membrane
Calculated MW:87kDa
Observed MW:90kDa

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. Like other members of this convertase family, the product of this gene specifically cleaves substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140, and may play a role in tumor progression. Unlike SARS-CoV and other coronaviruses, the spike protein of SARS-CoV-2 is thought to be uniquely cleaved by this protease. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:5045
Clone Number:ARC1221
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using Furin Rabbit mAb (CAB5043) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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