The Fumarylacetoacetase Polyclonal Antibody (CAB6586) is a valuable tool for researchers studying Fumarylacetoacetase, an enzyme involved in the tyrosine degradation pathway. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting Fumarylacetoacetase in human samples, particularly in Western blot applications. By targeting the Fumarylacetoacetase protein, this antibody enables precise quantification and localization of the enzyme in various cell types.Fumarylacetoacetase plays a critical role in the breakdown of tyrosine and defects in its function have been associated with hereditary tyrosinemia type 1, a rare metabolic disorder.
Research into Fumarylacetoacetase is essential for understanding the molecular mechanisms underlying this condition and developing targeted therapies. The CAB6586 antibody provides a valuable tool for investigating the function and regulation of Fumarylacetoacetase in both normal and diseased states, making it an indispensable resource for biochemical and genetic studies.
Product Name:
FAH Rabbit Polyclonal Antibody
SKU:
CAB6586
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-419 of human FAH (NP_000128.1).
Predicted to enable fumarylacetoacetase activity. Predicted to be involved in L-phenylalanine catabolic process; homogentisate catabolic process; and tyrosine catabolic process. Predicted to act upstream of or within arginine catabolic process. Located in extracellular exosome. Implicated in tyrosinemia type I.
Purification Method:
Affinity purification
Gene ID:
2184
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using FAH Rabbit pAb (CAB6586) at 1:10000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime: 180s.
