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Fumarase Monoclonal Antibody [PAT3F6AT] (CPAB0205)

SKU:
CPAB0205
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
PAT3F6AT
Applications:
WB
ELISA
FC
$179
Frequently bought together:

Description

system_update_alt Datasheet

Fumarase Monoclonal Antibody [PAT3F6AT] (CPAB0205)

The Fumarase Polyclonal Antibody (CPAB0205) is a valuable tool for researchers studying the enzyme fumarase, which plays a crucial role in the citric acid cycle and energy production in cells. This antibody, raised in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the fumarase protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in biochemistry, metabolism, and cancer research.Fumarase, also known as fumarate hydratase, is essential for converting fumarate to malate in the citric acid cycle, a key metabolic pathway in cells.

Dysregulation of fumarase activity has been linked to various conditions, including cancer and hereditary cancer syndromes such as hereditary leiomyomatosis and renal cell cancer (HLRCC). Understanding the role of fumarase in these diseases is critical for developing targeted therapies and diagnostic tools.Overall, the Fumarase Polyclonal Antibody (CPAB0205) offers researchers a reliable and specific tool for studying fumarase function and its implications in cellular metabolism and disease. Its versatility and accuracy make it a valuable asset for advancing scientific knowledge in biochemistry and related fields.

Product Name:Fumarase Antibody
Product Sku:CPAB0205
Size:5μg
Host Species:Mouse
Immunogen:Anti-human Fumarase mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human Fumarase amino acids 44-51 purified from Ecoli.
Clone:PAT3F6AT.
Reactivity:Human
Applications:Western Blot, ELISA, Flow Cytometry
Purification Method:Fumarase antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2a
Background:Fumarase is an enzymatic factor of Krebs cycle, which catalyzes the formation of L-malate from fumarate. Fumarase exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is aimed to the mitochondrion, where the removal of the extension results in the same form as in the cytoplasm. Fumarase is similar to a number of thermostable Class-2 fumarases and functions as a homotetramer. Mutations in the Fumarase gene causes fumarase deficiency and leads to progressive encephalopathy, cerebral atrophy and developmental delay. Fumarase enzyme is also thought to act as a tumor suppressor. Leydig cell tumors are caused by Fumarase mutations and represents one of the first reports of germline mutations in any type of adult testicular tumor.
Synonyms:MCL, LRCC, HLRCC, MCUL1, FH, Fumarate hydratase, Fumarase.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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