The FUCA2 Polyclonal Antibody (CAB12211) is a valuable tool for researchers studying FUCA2, a key enzyme involved in glycosphingolipid metabolism. This antibody, raised in rabbits, exhibits high specificity and sensitivity for detecting FUCA2 in human samples, particularly in Western blot applications.FUCA2 plays a crucial role in the breakdown of complex carbohydrates, specifically in the degradation of fucosylated glycoconjugates. Dysregulation of FUCA2 activity has been implicated in various metabolic disorders and diseases, making it a promising target for therapeutic interventions.
By using the FUCA2 Polyclonal Antibody, researchers can accurately detect and analyze FUCA2 expression in different cell types, providing insights into its function and potential implications in disease pathology. This antibody is a valuable tool for studies in glycobiology, metabolism, and biomedical research aimed at understanding the role of FUCA2 in health and disease.
Product Name:
FUCA2 Rabbit Polyclonal Antibody
SKU:
CAB12211
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 118-467 of human FUCA2 (NP_114409.2).
This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells.
Purification Method:
Affinity purification
Gene ID:
2519
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FUCA2 Rabbit pAb (CAB12211) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
