FUBP1 Rabbit Polyclonal Antibody (CAB5587)
- SKU:
- CAB5587
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | FUBP1 Rabbit Polyclonal Antibody |
SKU: | CAB5587 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 302-644 of human FUBP1 (NP_003893.2). |
Sequence: | QNDA GVRI QFKP DDGT TPER IAQI TGPP DRCQ HAAE IITD LLRS VQAG NPGG PGPG GRGR GRGQ GNWN MGPP GGLQ EFNF IVPT GKTG LIIG KGGE TIKS ISQQ SGAR IELQ RNPP PNAD PNMK LFTI RGTP QQID YARQ LIEE KIGG PVNP LGPP VPHG PHGV PGPH GPPG PPGP GTPM GPYN PAPY NPGP PGPA PHGP PAPY APQG WGNA YPHW QQQA PPDP AKAG TDPN SAAW AAYY AHYY QQQA QPPP AAPA GAPT TTQT NGQG DQQN PAPA GQVD YTKA WEEY YKKM GQAV PAPT GAPP GGQP DYSA AWAE YYRQ QAAY YAQT SPQG MPQH PPAP QGQ |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:100 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | FBP; FUBP; hDH V; FUBP1 |
Positive Sample: | U-87MG,HeLa,HepG2,THP-1,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 68kDa |
Observed MW: | 79kDa |
The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 8880 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |