The FTL Polyclonal Antibody (CAB1768) is a valuable tool for researchers studying the FTL protein, which is involved in regulating iron metabolism and storage in the body. This antibody, generated in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding specifically to the FTL protein, this antibody enables the detection and analysis of FTL in various cell types, making it an ideal choice for studies in the fields of biochemistry and molecular biology.FTL, also known as ferritin light chain, plays a crucial role in maintaining iron homeostasis by storing excess iron in a safe, non-toxic form.
Dysregulation of FTL expression and function has been linked to various diseases, including iron overload disorders and neurodegenerative conditions. Investigating the function and regulation of FTL is essential for advancing our understanding of these diseases and developing targeted treatments to address them. By using the FTL Polyclonal Antibody (CAB1768), researchers can pursue important studies that contribute to our knowledge of iron metabolism and related health conditions.
Product Name:
Ferritin Light Chain Rabbit Polyclonal Antibody
SKU:
CAB1768
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human Ferritin Light Chain (NP_000137.2).
cytoplasm, cytosol, extracellular exosome, extracellular region
Calculated MW:
20kDa
Observed MW:
20kDa
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes.
Purification Method:
Affinity purification
Gene ID:
2512
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Ferritin Light Chain Rabbit pAb (CAB1768) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
