Ferritin Heavy Chain Rabbit Polyclonal Antibody (CAB1144)
The FTH1 Polyclonal Antibody (CAB1144) is specifically designed for research involving FTH1, a key player in iron metabolism and storage. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting. By binding to the FTH1 protein, this antibody enables the detection and analysis of FTH1 levels in different cell types, making it a valuable tool for studies in biology and medicine.FTH1, also known as ferritin heavy chain 1, is crucial for storing and releasing iron in cells, contributing to overall iron homeostasis.
Dysregulation of FTH1 is implicated in various diseases, including iron overload disorders and certain types of cancer. Therefore, investigating the role of FTH1 in these conditions can provide insights into disease mechanisms and potential therapeutic targets.Given the importance of FTH1 in iron metabolism and its implications in disease pathology, the FTH1 Polyclonal Antibody (CAB1144) serves as a valuable tool for researchers looking to unravel the complexities of iron regulation and its impact on health and disease.
Product Name:
Ferritin Heavy Chain Rabbit Polyclonal Antibody
SKU:
CAB1144
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-183 of human Ferritin Heavy Chain (NP_002023.2).
This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
Purification Method:
Affinity purification
Gene ID:
2495
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Ferritin Heavy Chain Rabbit pAb (CAB1144) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
