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Anti-FSCN1 Antibody (CAB13355)

SKU:
CAB13355
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 3 Anti-FSCN1 Antibody CAB13355
  • Cell Biology Antibodies 3 Anti-FSCN1 Antibody CAB13355
€139 - €419
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Description

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Anti-FSCN1 Antibody (CAB13355)

The FSCN1 Polyclonal Antibody (CAB13355) is a valuable tool for researchers studying the FSCN1 protein, which plays a key role in regulating cell morphology and motility. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to FSCN1, researchers can detect and analyze the protein in various cell types, making it ideal for studies in cell biology, cancer research, and developmental biology.

FSCN1, also known as fascin, is a crucial regulator of actin bundling and cell migration, making it a key player in processes such as cell adhesion and invasion. Its involvement in promoting tumor progression and metastasis highlights its potential as a therapeutic target for cancer treatment. Research into the function and regulation of FSCN1 is essential for advancing our understanding of cancer biology and developing targeted therapies to combat the disease.

Antibody Name:Anti-FSCN1 Antibody
Antibody SKU:CAB13355
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 260-380 of human FSCN1 (NP_003079.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, HeLa, U-251MG, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 260-380 of human FSCN1 (NP_003079.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CAQV VLQA ANER NVST RQGM DLSA NQDE ETDQ ETFQ LEID RDTK KCAF RTHT GKYW TLTA TGGV QSTA SSKN ASCY FDIE WRDR RITL RASN GKFV TSKK NGQL AASV ETAG DSEL FLMK L
Gene ID:6624
Uniprot:Q16658
Cellular Location:Cell junction, Cell projection, Cytoplasm, cytoskeleton, cytosol, filopodium, invadopodium, microvillus
Calculated MW:54kDa
Observed MW:55kDa
Synonyms:FSCN1, FAN1, HSN, SNL, p55, fascin
Background:This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.
UniProt Protein Function:Fascin: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Associates with beta-catenin. Ubiquitous. Belongs to the fascin family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cytoskeletal; Actin-binding

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: cytoplasm; stress fiber; cell junction; cytosol; actin cytoskeleton; filopodium

Molecular Function:protein binding, bridging; actin filament binding; protein binding; drug binding; actin binding

Biological Process: cell proliferation; actin filament bundle formation; cell migration; cell motility involved in cell locomotion; actin cytoskeleton organization and biogenesis

NCBI Summary:This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
UniProt Code:Q16658
NCBI GenInfo Identifier:2498357
NCBI Gene ID:6624
NCBI Accession:Q16658.3
UniProt Related Accession:Q16658
Molecular Weight:54kDa
NCBI Full Name:Fascin
NCBI Synonym Full Names:fascin actin-bundling protein 1
NCBI Official Symbol:FSCN1  
NCBI Official Synonym Symbols:HSN; SNL; p55; FAN1  
NCBI Protein Information:fascin
UniProt Protein Name:Fascin
UniProt Synonym Protein Names:55 kDa actin-bundling protein; Singed-like protein; p55
Protein Family:Fascin
UniProt Gene Name:FSCN1  
UniProt Entry Name:FSCN1_HUMAN
Anti-FSCN1 Antibody (CAB13355)Western blot analysis of extracts of various cell lines, using FSCN1 antibody (CAB13355) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
Anti-FSCN1 Antibody (CAB13355)Immunohistochemistry of paraffin-embedded human liver cancer using FSCN1 antibody (CAB13355) at dilution of 1:100 (40x lens).

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