The FRS3 Polyclonal Antibody (PAC02053) is a vital tool for researchers investigating FRS3, a crucial protein involved in regulating cellular signal transduction pathways. This antibody, produced in rabbits, has high specificity for human samples and has been rigorously tested for Western blot applications. By binding to the FRS3 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component for studies in cell signaling and cancer research.FRS3, also known as Fibroblast Growth Factor Receptor Substrate 3, is a key player in transducing signals from cell surface receptors to the nucleus, ultimately influencing cell growth, differentiation, and survival.
Its role in these pathways makes it a promising target for research into conditions like cancer and developmental disorders. Understanding the function of FRS3 is crucial for developing therapies that target aberrant signaling pathways in disease states.Overall, the FRS3 Polyclonal Antibody is a reliable tool for researchers seeking to delve deeper into the intricate mechanisms of cellular signaling and its implications in various disease states. Its specificity and reliability make it an indispensable resource for advancing knowledge in the fields of molecular biology and therapeutic development.
Antibody Name:
FRS3 Antibody (PACO22053)
Antibody SKU:
PACO22053
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human FRS3.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from COS-7 cells, using FRS3 antibody.
Background:
Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.
FRS3: Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 6p21.1Cellular Component: plasma membraneMolecular Function: protein binding; insulin receptor binding; fibroblast growth factor receptor bindingBiological Process: fibroblast growth factor receptor signaling pathway; signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]
