The FRS3 Polyclonal Antibody (PACO09348) is a valuable tool for researchers studying the FRS3 protein, a key player in cellular signaling pathways related to cell growth and proliferation. This rabbit polyclonal antibody is highly specific to human FRS3 and has been validated for use in Western blot applications to detect FRS3 protein levels in various cell types.FRS3, also known as Fibroblast Growth Factor Receptor Substrate 3, is involved in mediating cellular responses to growth factors and is implicated in multiple physiological processes, including tissue development and wound healing.
Dysregulation of FRS3 signaling has been linked to cancer progression and other diseases, highlighting its importance in cellular biology research.By targeting FRS3 with this antibody, researchers can gain insights into the role of FRS3 in normal cellular function and disease states, providing a basis for developing potential therapeutic interventions targeting FRS3-related pathways. This antibody is a valuable resource for studies in cancer biology, developmental biology, and signal transduction pathways involving FRS3.
FRS3: Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 6p21.1Cellular Component: plasma membraneMolecular Function: protein binding; insulin receptor binding; fibroblast growth factor receptor bindingBiological Process: fibroblast growth factor receptor signaling pathway; signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]
