The FRS3 Polyclonal Antibody (PACO00826) is a valuable tool for researchers studying the FRS3 protein, a key player in signaling pathways that regulate cell growth and survival. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the FRS3 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it ideal for investigations in cell biology and cancer research.
FRS3, also known as fibroblast growth factor receptor substrate 3, is involved in mediating signals from growth factors and cytokines to promote cell proliferation and differentiation. Its role in cell signaling pathways makes it a crucial factor to study in the context of cancer and other diseases characterized by abnormal cell growth and survival. Understanding the function of FRS3 may provide insights into potential therapeutic approaches for targeting these pathways in disease treatment.
Antibody Name:
FRS3 Antibody
Antibody SKU:
PACO00826
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Monkey
Immunogen:
synthesized peptide derived from the Internal region of human FRS3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
FRS3: Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 6p21.1Cellular Component: plasma membraneMolecular Function: protein binding; insulin receptor binding; fibroblast growth factor receptor bindingBiological Process: fibroblast growth factor receptor signaling pathway; signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]
