| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q7Z6J6 |
| NCBI GenInfo Identifier: | 34190399 |
| NCBI Gene ID: | 26269 |
| NCBI Accession: | BC014679 |
| UniProt Secondary Accession: | Q7Z6J6,Q6UWN4, Q8IWE1, Q9NRP5, Q9UKC4, B2RB40, D3DP41 G5E9Z0 |
| UniProt Related Accession: | Q7Z6J6,Q9NRD0 |
| Molecular Weight: | 32,426 Da |
| NCBI Full Name: | Homo sapiens F-box protein 8, mRNA |
| NCBI Synonym Full Names: | F-box protein 8 |
| NCBI Official Symbol: | FBXO8Â Â |
| NCBI Official Synonym Symbols: | FBS; DC10; FBX8Â Â |
| NCBI Protein Information: | F-box only protein 8 |
| UniProt Protein Name: | FERM domain-containing protein 5 |
| UniProt Synonym Protein Names: | |
| Protein Family: | F-box only protein |
| UniProt Gene Name: | FRMD5Â Â |
| UniProt Entry Name: | FRMD5_HUMAN |
