FZD6 Rabbit Polyclonal Antibody (CAB10503)
- SKU:
- CAB10503
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | FZD6 Rabbit Polyclonal Antibody |
SKU: | CAB10503 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-201 of human FZD6 (NP_003497.2). |
Sequence: | HSLF TCEP ITVP RCMK MAYN MTFF PNLM GHYD QSIA AVEM EHFL PLAN LECS PNIE TFLC KAFV PTCI EQIH VVPP CRKL CEKV YSDC KKLI DTFG IRWP EELE CDRL QYCD ETVP VTFD PHTE FLGP QKKT EQVQ RDIG FWCP RHLK TSGG QGYK FLGI DQCA PPCP NMYF KSDE LEFA KSF |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:2000 |
Synonyms: | FZ6; FZ-6; HFZ6; NDNC1; NDNC10; FZD6 |
Positive Sample: | mouse kidney,rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Apical cell membrane, Cell membrane, Cell surface, Cytoplasmic vesicle membrane, Membrane, Multi-pass membrane protein. |
Calculated MW: | 79kDa |
Observed MW: | 79kDa |
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.
Purification Method: | Affinity purification |
Gene ID: | 8323 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |