The Frizzled 1 Polyclonal Antibody (CAB10809) is a powerful tool for researchers studying the Frizzled 1 protein, a key player in the Wnt signaling pathway. This antibody, developed in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to Frizzled 1, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in developmental biology, cancer research, and stem cell biology.Frizzled 1 is a critical receptor involved in the transmission of signals that regulate cell growth, differentiation, and migration.
Dysregulation of the Wnt pathway, in which Frizzled 1 plays a central role, has been linked to various diseases, including cancer and developmental disorders. As such, understanding the function of Frizzled 1 is essential for unraveling the molecular mechanisms underlying these conditions and identifying potential therapeutic targets.Researchers can rely on the Frizzled 1 Polyclonal Antibody to accurately detect and study this pivotal protein, helping to advance our knowledge of cellular signaling pathways and potentially leading to the development of novel treatments for a range of pathological conditions.
Product Name:
FZD1 Rabbit Polyclonal Antibody
SKU:
CAB10809
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 548-647 of human FZD1 (NP_003496.1).
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.
Purification Method:
Affinity purification
Gene ID:
8321
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse kidney, using FZD1 Rabbit pAb (CAB10809) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
