The Frem2 Polyclonal Antibody (CAB15980) is developed for researchers studying Frem2, a protein involved in cell adhesion and extracellular matrix organization. This antibody is produced in rabbits and has high reactivity with human samples, making it suitable for use in Western blot applications. By specifically binding to the Frem2 protein, this antibody allows for the detection and analysis of Frem2 in various cell types, making it an essential tool for studies in cell biology and developmental research.Frem2 is a critical protein in the formation of tissues and organs during development, particularly in processes like neural tube closure and heart development.
Understanding the function of Frem2 is essential for uncovering the mechanisms underlying developmental disorders and congenital abnormalities. The Frem2 Polyclonal Antibody provides researchers with a valuable tool for investigating the role of Frem2 in these processes, ultimately contributing to advancements in developmental biology and potential therapeutic interventions for associated conditions.
Product Name:
FREM2 Rabbit Polyclonal Antibody
SKU:
CAB15980
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 47-300 of human FREM2 (NP_997244.4).
Cell membrane, Extracellular side, Single-pass type I membrane protein.
Calculated MW:
351kDa
Observed MW:
351kDa
This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The encoded protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions. This protein is important for the integrity of skin and renal epithelia. Mutations in this gene are associated with Fraser syndrome.
Purification Method:
Affinity purification
Gene ID:
341640
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FREM2 Rabbit pAb (CAB15980) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 150s.
