FREM1 Rabbit Polyclonal Antibody (CAB16603)
- SKU:
- CAB16603
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | FREM1 Rabbit Polyclonal Antibody |
SKU: | CAB16603 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1880-2179 of human FREM1 (NP_659403.4). |
Sequence: | GSSS STTS GSFH LERR PLPS SMQL AVIR GDTL RGFD STDL SQRK LRTR GNGK TVRP SSVY RNGT DIIY NYHG IVSL KLED DSFP THKR KAKV SIIS QPQK TIKV AELP QADK VEST TDSH FPRQ DQLP SFPK NCTL ELKG LFHF EEGI QKLY QCNG IAWK AWSP QTKD VEDK SCPA GWHQ HSGY CHIL ITEQ KGTW NAAA QACR EQYL GNLV TVFS RQHM RWLW DIGG RKSF WIGL NDQV HAGH WEWI GGEP VAFT NGRR GPSQ RSKL GKSC VLVQ RQGK WQTK DCRR AKPH NYVC SRKL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | BNAR; MOTA; TILRR; TRIGNO2; C9orf143; C9orf145; C9orf154; FREM1 |
Positive Sample: | 293T,K-562,HepG2,Mouse kidney,Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, basement membrane, extracellular matrix, extracellular space. |
Calculated MW: | 244kDa |
Observed MW: | 72kDa |
This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation.
Purification Method: | Affinity purification |
Gene ID: | 158326 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |