The FREM1 Polyclonal Antibody (CAB16603) is developed for research focusing on FREM1, a protein involved in extracellular matrix organization and cell adhesion processes. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By targeting the FREM1 protein, this antibody allows for the identification and investigation of FREM1 expression in various cell types, making it an essential tool for studies in developmental biology and tissue remodeling.FREM1, also known as FRAS1 related extracellular matrix protein 1, plays a crucial role in maintaining tissue integrity and regulating cell behavior during development and homeostasis.
Its involvement in extracellular matrix assembly suggests its importance in processes such as cell migration, adhesion, and differentiation. Research on FREM1 is key to understanding its function in development and potential implications in diseases related to tissue remodeling and morphogenesis.Overall, the FREM1 Polyclonal Antibody provides researchers with a valuable tool for studying FREM1 expression and function, shedding light on its role in tissue development and maintenance. Its versatility in detecting FREM1 in various experimental settings makes it an indispensable resource for investigations on extracellular matrix biology and cellular interactions.
Product Name:
FREM1 Rabbit Polyclonal Antibody
SKU:
CAB16603
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1880-2179 of human FREM1 (NP_659403.4).
This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation.
Purification Method:
Affinity purification
Gene ID:
158326
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FREM1 Rabbit pAb (CAB16603) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
