The FRAT1 Polyclonal Antibody (CAB16093) is a valuable tool for researchers studying FRAT1, a key regulator of the Wnt signaling pathway involved in cell proliferation and differentiation. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.FRAT1, or frequently rearranged in advanced T-cell lymphomas 1, plays a crucial role in regulating Wnt signaling, a pathway that is dysregulated in various cancers and developmental disorders. By detecting and analyzing FRAT1 expression in different cell types, researchers can gain insights into its function and potential therapeutic implications in cancer biology.
Understanding the role of FRAT1 in Wnt signaling is essential for developing targeted therapies that can modulate this pathway and potentially inhibit tumor growth and progression. The FRAT1 Polyclonal Antibody is a valuable resource for investigating the molecular mechanisms underlying Wnt signaling and its implications in cancer research.
Product Name:
FRAT1 Rabbit Polyclonal Antibody
SKU:
CAB16093
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human FRAT1 (NP_005470.2).
The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis.
Purification Method:
Affinity purification
Gene ID:
10023
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FRAT1 Rabbit pAb (CAB16093) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
