The FPR3 Antibody (PACO19675) is a high-quality antibody designed for research involving FPR3, a receptor involved in immune regulation and inflammation. This polyclonal antibody is raised in rabbits and is highly reactive with human samples, making it ideal for use in Western blot applications. By binding to the FPR3 protein, this antibody enables the detection and analysis of FPR3 in various cell types, allowing for detailed studies in immunology and inflammatory conditions.FPR3, also known as formyl peptide receptor 3, plays a crucial role in the regulation of immune responses and inflammation.
Its involvement in these processes makes it a key target for research into diseases such as autoimmune disorders, chronic inflammatory conditions, and cancer. Understanding the function of FPR3 is essential for developing potential therapies that target or modulate immune responses in these disease contexts.Overall, the FPR3 Antibody (PACO19675) is a valuable tool for researchers studying immune regulation and inflammatory processes, offering reliable and specific detection of FPR3 in human samples for a wide range of experimental applications.
Antibody Name:
FPR3 Antibody (PACO19675)
Antibody SKU:
PACO19675
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human FPR3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO19675(FPR3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19675(FPR3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The N-formyl peptide receptor (FPR) family is comprised of three members, FPR, FPR3 (also designated FPRL1, lipoxin A4 receptor, FPRH1 or FPR2) and FPR like-2 (FPRL2), all of which are chemotactic G protein-coupled receptors that contain seven transmembrane domains. These receptors are found on the surface of phagocytic leukocytes, such as neutrophils and monocytes, and each family member contains specific residues, which are responsible for determining its ligand specificity. FPR3 is a promiscuous receptor that binds to several ligands, including lipoxin A4, N-formyl-methionyl-leucyl-phenylalanine (fMLP), serum amyloid A (SAA), prion peptide and the 42 amino acid, form of β amyloid. Upon activation, FPR3 induces migration and calcium mobilization in human monocytes and neutrophils and is involved in inflammatory and host defense responses. FPR3 may mediate inflammation in prion and AlzheimerÂ’s diseases, which makes it a potential target for therapeutic agents.
Synonyms:
formyl peptide receptor 3
UniProt Protein Function:
FPR3: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.Protein type: Receptor, GPCR; GPCR, family 1; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 19q13.3-q13.4Cellular Component: plasma membraneBiological Process: cell motility; signal transduction
