The Foxp3 Polyclonal Antibody (CAB12051) is a valuable tool for researchers studying Foxp3, a key transcription factor involved in the development and function of regulatory T cells. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for a variety of immunology studies.Foxp3 is essential for maintaining immune tolerance and preventing autoimmune diseases by regulating the activity of T cells. Dysfunction of regulatory T cells can lead to the development of various immune-related disorders, making Foxp3 a crucial target for research in fields such as autoimmune diseases, cancer immunotherapy, and transplantation.
The Foxp3 Polyclonal Antibody is validated for use in Western blot applications, allowing for the detection and analysis of Foxp3 protein levels in different cell types. By understanding the mechanisms and functions of Foxp3, researchers can gain insights into immune regulation and potentially develop targeted therapies for various diseases.
Product Name:
FOXP3 Rabbit Polyclonal Antibody
SKU:
CAB12051
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 70-180 of human FOXP3 (NP_054728.2).
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
50943
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of Rat pancreas, using FOXP3 antibody (CAB12051) at 1:800 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
