The Foxp2 Polyclonal Antibody (CAB5677) is a vital tool for researchers studying Foxp2, a transcription factor associated with speech and language development in humans. This antibody, generated in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By binding to the Foxp2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in neurobiology and developmental genetics.
Foxp2 has been identified as a key regulator of speech and language abilities, making it a prime target for investigating language disorders and developmental delays. Research into Foxp2 has implications for understanding the genetic basis of speech production and language acquisition, as well as the role of transcription factors in neurodevelopment. By studying Foxp2, researchers can gain insights into the molecular mechanisms underlying language evolution and communication disorders.
Product Name:
FOXP2 Rabbit Polyclonal Antibody
SKU:
CAB5677
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 590-715 of human FOXP2 (NP_055306.1).
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
Purification Method:
Affinity purification
Gene ID:
93986
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using FOXP2 antibody (CAB5677) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
