The FOXO4 Polyclonal Antibody (CAB3307) is a valuable tool for researchers studying the FOXO4 protein, which plays a crucial role in regulating cellular processes such as apoptosis, DNA repair, and oxidative stress response. This antibody is raised in rabbits and is highly reactive with human samples, making it ideal for use in Western blot applications for detection and analysis of FOXO4 in various cell types.FOXO4, a member of the FOXO family of transcription factors, is known for its tumor-suppressive properties and its ability to promote longevity by regulating cell cycle arrest and DNA damage repair pathways.
Dysregulation of FOXO4 has been linked to various diseases including cancer, neurodegenerative disorders, and metabolic diseases. Understanding the function of FOXO4 is essential for developing targeted therapies that can modulate its activity in disease contexts.With its high specificity and sensitivity, the FOXO4 Polyclonal Antibody (CAB3307) is a valuable tool for researchers seeking to further explore the role of FOXO4 in cellular processes and disease development. Its applications in immunology, oncology, and aging research make it a versatile tool for studying the intricate mechanisms of FOXO4 signaling.
Product Name:
FOXO4 Rabbit Polyclonal Antibody
SKU:
CAB3307
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 230-341 of human FOXO4 (NP_005929.2).
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4303
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using (CAB3307) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
