The FoxO3 Polyclonal Antibody (CAB0102) is a valuable tool for researchers studying the FoxO3 protein, a key transcription factor involved in various cellular processes such as apoptosis, cell cycle regulation, and oxidative stress response. This antibody is produced in rabbits and has been validated for use in Western blot applications with high reactivity towards human samples.FoxO3 is known for its role in promoting longevity and regulating cellular functions that impact aging, metabolism, and stress resistance. By targeting the FoxO3 protein, researchers can gain insights into its mechanisms of action and its potential as a therapeutic target in age-related diseases, cancer, and metabolic disorders.
With its specificity and reliability in detecting FoxO3 protein in different cell types, the FoxO3 Polyclonal Antibody is an essential tool for studies in aging, cancer biology, and metabolic health. It enables accurate detection and analysis of FoxO3 levels, allowing researchers to further understand its function and potential implications in various disease contexts.
Product Name:
FoxO3a Rabbit Polyclonal Antibody
SKU:
CAB0102
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 558-635 of mouse FOXO3A (NP_062714.1).
Sequence:
LSDS SSLG SAKH QQQS PASQ SMQT LSDS LSGS SLYS ASAN LPVM GHDK FPSD LDLD MFNG SLEC DMES IIRS ELMD AD
Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and mitochondrial transcription factor activity. Involved in several processes, including mitochondrial transcription; positive regulation of muscle atrophy; and positive regulation of pri-miRNA transcription by RNA polymerase II. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; female gonad development; and neuronal stem cell population maintenance. Located in cytosol; mitochondrial outer membrane; and nucleus. Part of protein-containing complex. Colocalizes with mitochondrial matrix. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system. Used to study dermoid cyst of ovary. Orthologous to human FOXO3 (forkhead box O3).
Purification Method:
Affinity purification
Gene ID:
56484
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using FOXO3A Rabbit pAb (CAB0102) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
