The FOXO1 Polyclonal Antibody (CAB13862) is specifically designed for research involving FOXO1, a transcription factor that plays a crucial role in regulating cell growth, differentiation, and metabolism. This antibody, produced using rabbit immunization, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the FOXO1 protein, this antibody enables accurate detection and analysis in various cell types, making it an essential tool for studies in molecular biology and cancer research.
FOXO1, also known as Forkhead box protein O1, is involved in numerous cellular processes including apoptosis, cellular stress responses, and regulation of glucose metabolism. Dysregulation of FOXO1 is associated with various diseases, making it a promising target for therapeutic interventions in conditions such as cancer, diabetes, and cardiovascular diseases. Understanding the mechanisms underlying FOXO1 activity is crucial for developing targeted therapies that can effectively modulate cellular function in disease states.
Product Name:
FOXO1 Rabbit Polyclonal Antibody
SKU:
CAB13862
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 340-580 of human FOXO1 (NP_002006.2).
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
Purification Method:
Affinity purification
Gene ID:
2308
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse thymus, using FOXO1 Rabbit pAb (CAB13862) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
