The FOXN1 Polyclonal Antibody (PAC017902) is a valuable tool for researchers studying FOXN1, a transcription factor known for its role in thymus development and T-cell differentiation. This antibody, generated in rabbits, exhibits high specificity for FOXN1 in human samples and is suitable for use in various applications including Western blotting.FOXN1 is essential for the development and function of the thymus, a primary organ in the immune system where T-cells mature. Dysregulation of FOXN1 has been linked to thymic involution and impaired T-cell production, highlighting its importance in immune system function.
Research on FOXN1 is crucial for advancing understanding of immune system development and for exploring potential therapeutic targets in diseases related to immune dysfunction.The FOXN1 Polyclonal Antibody is a reliable tool for detecting and studying FOXN1 protein expression in different cell types and tissues. Its use is particularly beneficial in immunology research, where it can provide insights into thymic function and T-cell development. By targeting FOXN1, researchers can uncover new pathways involved in immune regulation and potentially identify novel strategies for treating immune-related disorders.
Antibody Name:
FOXN1 Antibody (PACO17902)
Antibody SKU:
PACO17902
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human FOXN1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO17902(FOXN1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed.
Synonyms:
forkhead box N1
UniProt Protein Function:
FOXN1: Transcriptional regulator involved in development. Defects in FOXN1 are the cause of T-cell immunodeficiency congenital alopecia and nail dystrophy (TIDAND). A disorder characterized by the association of congenital alopecia, severe T-cell immunodeficiency, and ridging and pitting of all nails.Protein type: DNA-binding; Transcription factor; Cell development/differentiationChromosomal Location of Human Ortholog: 17q11.2Biological Process: defense response; epidermis development; organ morphogenesis; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoterDisease: T-cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy
UniProt Protein Details:
NCBI Summary:
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]
