FOXN1 Antibody (PACO17901)
- SKU:
- PACO17901
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
FOXN1 Antibody (PACO17901)
The FOXN1 Polyclonal Antibody (PAC017901) is a valuable tool for researchers studying the FOXN1 protein, a transcription factor critical for thymus development and T-cell maturation. Raised in rabbits, this antibody is highly specific for human samples and has been validated for use in Western blot applications. By binding to the FOXN1 protein, this antibody allows for the detection and analysis of FOXN1 expression in a variety of cell types, making it ideal for research in immunology and autoimmune diseases.
FOXN1 is essential for the development and maintenance of the thymus, the primary organ responsible for T-cell maturation and central tolerance. Dysregulation of FOXN1 has been implicated in various autoimmune disorders and immune deficiencies, making it a key target for research into these conditions. Understanding the role of FOXN1 in immune function is crucial for the development of therapeutic interventions aimed at restoring immune homeostasis in diseases where FOXN1 function is compromised.
| Antibody Name: | FOXN1 Antibody (PACO17901) |
| Antibody SKU: | PACO17901 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human FOXN1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO17901(FOXN1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. |
| Synonyms: | forkhead box N1 |
| UniProt Protein Function: | FOXN1: Transcriptional regulator involved in development. Defects in FOXN1 are the cause of T-cell immunodeficiency congenital alopecia and nail dystrophy (TIDAND). A disorder characterized by the association of congenital alopecia, severe T-cell immunodeficiency, and ridging and pitting of all nails.Protein type: DNA-binding; Transcription factor; Cell development/differentiationChromosomal Location of Human Ortholog: 17q11.2Biological Process: defense response; epidermis development; organ morphogenesis; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoterDisease: T-cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy |
| UniProt Protein Details: | |
| NCBI Summary: | Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15353 |
| NCBI GenInfo Identifier: | 13124629 |
| NCBI Gene ID: | 8456 |
| NCBI Accession: | O15353.1 |
| UniProt Secondary Accession: | O15353,O15352, B2R9Q7 |
| UniProt Related Accession: | O15353 |
| Molecular Weight: | 68,925 Da |
| NCBI Full Name: | Forkhead box protein N1 |
| NCBI Synonym Full Names: | forkhead box N1 |
| NCBI Official Symbol: | FOXN1Â Â |
| NCBI Official Synonym Symbols: | WHN; RONU; FKHL20Â Â |
| NCBI Protein Information: | forkhead box protein N1 |
| UniProt Protein Name: | Forkhead box protein N1 |
| UniProt Synonym Protein Names: | Winged-helix transcription factor nude |
| Protein Family: | Forkhead box protein |
| UniProt Gene Name: | FOXN1Â Â |
| UniProt Entry Name: | FOXN1_HUMAN |
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