The FOXL1 Polyclonal Antibody (PAC017899) is a valuable tool for researchers studying FOXL1, a transcription factor involved in the regulation of cell differentiation and development. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blot and immunohistochemistry applications. By specifically binding to the FOXL1 protein, this antibody allows for the detection and analysis of FOXL1 expression in various cell types, making it ideal for studies in developmental biology and cancer research.
FOXL1 is known for its role in regulating cell fate decisions and tissue development, particularly in the gastrointestinal tract and pancreas. Its involvement in these crucial processes highlights its importance in understanding diseases such as cancer and digestive disorders. By elucidating the functions of FOXL1, researchers can gain insights into potential therapeutic strategies for targeting FOXL1-related pathways in disease settings.
Antibody Name:
FOXL1 Antibody (PACO17899)
Antibody SKU:
PACO17899
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human FOXL1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cells, mouse intestinum tenue tissue, Primary antibody: PACO17899(FOXL1 Antibody) at dilution 1/850, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds.
Background:
This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors.
Synonyms:
forkhead box L1
UniProt Protein Function:
FOXL1: Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors.
UniProt Protein Details:
Protein type:DNA-binding
Chromosomal Location of Human Ortholog: 16q24
Cellular Component: nucleus
Molecular Function:DNA binding; sequence-specific DNA binding; DNA bending activity; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; organ morphogenesis; heart development; proteoglycan biosynthetic process; multicellular organismal development; regulation of Wnt receptor signaling pathway; visceral mesoderm-endoderm interaction involved in midgut development
NCBI Summary:
This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. [provided by RefSeq, Nov 2012]
