The FOX L1 Polyclonal Antibody (PAC017898) is a cutting-edge tool for researchers studying the FOX L1 protein, a transcription factor crucial for the development and function of the nervous system. This antibody, produced in rabbits, shows high reactivity with human samples and has been rigorously validated for use in techniques such as Western blotting.FOX L1 is known for its role in promoting the differentiation and maintenance of neural stem cells, as well as its involvement in neuronal migration and synaptic plasticity. Dysregulation of FOX L1 has been linked to various neurological disorders, making it a promising target for therapeutic interventions.
By targeting the FOX L1 protein, researchers can gain valuable insights into the mechanisms underlying nervous system development and function. This antibody enables precise detection and analysis of FOX L1 in different cell types, making it an invaluable tool for studies in neuroscience and neurodevelopmental disorders.Unlock the potential of your research with the FOX L1 Polyclonal Antibody from AssayGenie.
Antibody Name:
FOXL1 Antibody (PACO17898)
Antibody SKU:
PACO17898
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human FOXL1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: PACO17898(FOXL1 Antibody) at dilution 1/850, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds.
Background:
This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors.
Synonyms:
forkhead box L1
UniProt Protein Function:
FOXL1: Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors.
UniProt Protein Details:
Protein type:DNA-binding
Chromosomal Location of Human Ortholog: 16q24
Cellular Component: nucleus
Molecular Function:DNA binding; sequence-specific DNA binding; DNA bending activity; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; organ morphogenesis; heart development; proteoglycan biosynthetic process; multicellular organismal development; regulation of Wnt receptor signaling pathway; visceral mesoderm-endoderm interaction involved in midgut development
NCBI Summary:
This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. [provided by RefSeq, Nov 2012]
