null

FOXL1 Antibody (PACO00819)

SKU:
PACO00819
Product Type:
Antibody
Reactivity:
Human
NHP - Monkey
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$323
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

FOXL1 Antibody (PACO00819)

The FoxL1 Polyclonal Antibody (PACO00819) is a valuable tool for researchers studying the FoxL1 protein, a transcription factor involved in various biological processes, including cellular proliferation and differentiation. This antibody, raised in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the FoxL1 protein, this antibody allows for the detection and analysis of FoxL1 expression in different cell types, making it ideal for studies in developmental biology, cancer research, and tissue regeneration.

FoxL1, also known as Forkhead Box L1, plays a critical role in regulating cell fate and tissue development, making it a key player in processes such as epithelial-mesenchymal transition and stem cell maintenance. Dysregulation of FoxL1 has been implicated in various diseases, including cancer, fibrosis, and gastrointestinal disorders. By studying the function and expression of FoxL1 using this antibody, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.

Antibody Name:FOXL1 Antibody
Antibody SKU:PACO00819
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Monkey
Immunogen:synthesized peptide derived from the Internal region of human FoxL1.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:FOXL1; FKHL11; FREAC7; Forkhead box protein L1; Forkhead-related protein FKHL11; Forkhead-related transcription factor 7; FREAC-7
UniProt Protein Function:FOXL1: Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 16q24

Cellular Component: nucleus

Molecular Function:DNA binding; sequence-specific DNA binding; DNA bending activity; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; organ morphogenesis; heart development; proteoglycan biosynthetic process; multicellular organismal development; regulation of Wnt receptor signaling pathway; visceral mesoderm-endoderm interaction involved in midgut development

NCBI Summary:This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. [provided by RefSeq, Nov 2012]
UniProt Code:Q12952
NCBI GenInfo Identifier:13638268
NCBI Gene ID:2300
NCBI Accession:Q12952.2
UniProt Secondary Accession:Q12952,Q17RR1, Q9H242,
UniProt Related Accession:Q12952
Molecular Weight:345
NCBI Full Name:Forkhead box protein L1
NCBI Synonym Full Names:forkhead box L1
NCBI Official Symbol:FOXL1  
NCBI Official Synonym Symbols:FKH6; FKHL11; FREAC7  
NCBI Protein Information:forkhead box protein L1; forkhead-like 11; forkhead-related protein FKHL11; forkhead-related transcription factor 7
UniProt Protein Name:Forkhead box protein L1
UniProt Synonym Protein Names:Forkhead-related protein FKHL11; Forkhead-related transcription factor 7; FREAC-7
Protein Family:Forkhead box protein
UniProt Gene Name:FOXL1  
UniProt Entry Name:FOXL1_HUMAN

Related Products