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FOXC1/FOXC2 Antibody (PACO02739)

SKU:
PACO02739
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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FOXC1/FOXC2 Antibody (PACO02739)

Based on the information from the provided URL, the FOXC1/FOXC2 Antibody (PAC02739) is a valuable tool for researchers studying the FOX transcription factors FOXC1 and FOXC2. These transcription factors play crucial roles in development, particularly in the formation of blood vessels and lymphatic vessels. The antibody, which is polyclonal, is able to specifically detect FOXC1 and FOXC2 proteins in human samples, making it an excellent choice for a variety of research applications.The FOXC1/FOXC2 Antibody (PAC02739) is validated for use in techniques such as Western blotting, immunohistochemistry, and immunofluorescence, allowing researchers to analyze the expression and localization of FOXC1 and FOXC2 in different cell types and tissues.

By understanding the functions of these transcription factors, researchers can gain insights into mechanisms of angiogenesis and lymphangiogenesis, as well as their roles in diseases such as cancer and lymphedema.Overall, the FOXC1/FOXC2 Antibody (PAC02739) is a valuable tool for studying the biological functions of FOXC1 and FOXC2, providing researchers with a reliable means of detecting and analyzing these important transcription factors in various research contexts.

Antibody Name:FOXC1/FOXC2 Antibody
Antibody SKU:PACO02739
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the Internal region of human FoxC1/2.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:FOXC1; FKHL7; FREAC3; Forkhead box protein C1; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3; FOXC2; FKHL14; MFH1; Forkhead box protein C2; Forkhead-related protein FKHL14; Mesenchyme fork head protein 1;
UniProt Protein Function:FOXC1: Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding; Cell cycle regulation; Cell development/differentiation

Chromosomal Location of Human Ortholog: 6p25

Cellular Component: cytoplasm; nuclear heterochromatin; nucleoplasm; nucleus

Molecular Function:DNA bending activity; DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding

Biological Process: cell migration; cell proliferation; eye development; heart development; mesenchymal cell development; negative regulation of angiogenesis; negative regulation of mitotic cell cycle; odontogenesis of dentine-containing teeth; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent

Disease: Axenfeld-rieger Syndrome, Type 3; Iridogoniodysgenesis, Type 1

NCBI Summary:This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008]
UniProt Code:Q12948
NCBI GenInfo Identifier:13638267
NCBI Gene ID:2296
NCBI Accession:Q12948.3
UniProt Secondary Accession:Q12948,Q86UP7, Q9BYM1, Q9NUE5, Q9UDD0, Q9UP06,
UniProt Related Accession:Q12948
Molecular Weight:56,789 Da
NCBI Full Name:Forkhead box protein C1
NCBI Synonym Full Names:forkhead box C1
NCBI Official Symbol:FOXC1  
NCBI Official Synonym Symbols:ARA; IGDA; IHG1; FKHL7; IRID1; RIEG3; FREAC3; FREAC-3  
NCBI Protein Information:forkhead box protein C1
UniProt Protein Name:Forkhead box protein C1
UniProt Synonym Protein Names:Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3
Protein Family:Forkhead box protein
UniProt Gene Name:FOXC1  
UniProt Entry Name:FOXC1_HUMAN

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