The FOXB2 Polyclonal Antibody (PAC017881) is a valuable tool for researchers studying FOXB2, a transcription factor involved in various cellular processes, including differentiation and development. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically binds to the FOXB2 protein, allowing for accurate detection and analysis in a variety of cell types.FOXB2 is known for its role in regulating gene expression and cell fate determination, making it a key player in developmental biology and cancer research. Its functions in controlling cell proliferation and differentiation highlight its importance in understanding various diseases, including cancer and developmental disorders.
By investigating the activity of FOXB2, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets.Overall, the FOXB2 Polyclonal Antibody is a reliable tool for researchers interested in studying the functions of FOXB2 and its implications in various physiological and pathological processes. Its specificity and sensitivity make it an ideal choice for immunology, developmental biology, and cancer research studies.
Antibody Name:
FOXB2 Antibody (PACO17881)
Antibody SKU:
PACO17881
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human FOXB2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO17881(FOXB2 Antibody) at dilution 1/5, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO17881(FOXB2 Antibody) at dilution 1/5, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
FOX (Forkhead box) proteins are a family of transcription factors that play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and longevity. Many FOX proteins are important to embryonic development. The defining feature of FOX proteins is the forkhead box, a sequence of 80 to 100 amino acid, forming a motif that binds to DNA. This forkhead motif is also known as the winged helix due to the butterfly-like appearance of the loops in the protein structure of the domain. Forkhead genes are a subgroup of the helix-turn-helix class of proteins. The FOXF2 gene encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta.
