The FOXB2 Polyclonal Antibody (PAC017880) offered by AssayGenie is a valuable tool for researchers studying the FOXB2 protein. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it a reliable choice for Western blot applications. FOXB2 is a transcription factor that plays a crucial role in gene regulation and has been implicated in various cellular processes.By targeting the FOXB2 protein, this antibody allows for the detection and analysis of FOXB2 expression in different cell types, providing insight into its function and potential involvement in diseases such as cancer and developmental disorders.
The FOXB2 Polyclonal Antibody is an essential component for studies focused on understanding the role of FOXB2 in gene regulation and its impact on cellular pathways.
Antibody Name:
FOXB2 Antibody (PACO17880)
Antibody SKU:
PACO17880
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human FOXB2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO17880(FOXB2 Antibody) at dilution 1/5, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
FOX (Forkhead box) proteins are a family of transcription factors that play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and longevity. Many FOX proteins are important to embryonic development. The defining feature of FOX proteins is the forkhead box, a sequence of 80 to 100 amino acid, forming a motif that binds to DNA. This forkhead motif is also known as the winged helix due to the butterfly-like appearance of the loops in the protein structure of the domain. Forkhead genes are a subgroup of the helix-turn-helix class of proteins. The FOXF2 gene encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta.
