The FOXA2 Rabbit Monoclonal Antibody (CAB19053) is a powerful tool for researchers studying FOXA2, a transcription factor essential for development and function of the liver, pancreas, and other organs. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting FOXA2 in human samples, making it a reliable choice for Western blot applications.FOXA2, also known as hepatocyte nuclear factor 3-beta (HNF-3B), plays a crucial role in gene regulation and cell differentiation, making it a key player in various physiological processes.
Dysregulation of FOXA2 has been linked to diseases such as diabetes, cancer, and liver disorders, highlighting its importance in understanding pathophysiology and potential therapeutic targets.By using the FOXA2 Rabbit Monoclonal Antibody, researchers can explore the function of FOXA2 in different cell types and tissues, advancing knowledge in areas such as metabolism, development, and disease progression. Its versatility and reliability make it a valuable asset for studies in molecular biology, physiology, and biomedical research.
Product Name:
HNF3β/FOXA2 Rabbit Monoclonal Antibody
SKU:
CAB19053
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HNF3β/FOXA2 (Q9Y261).
WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
HNF3B; TCF3B; HNF-3-beta; HNF3β/FOXA2
Positive Sample:
HepG2,Rat lung
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
48kDa
Observed MW:
52kDa
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
3170
Clone Number:
ARC0391
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using HNF3β/FOXA2 Rabbit mAb (CAB19053) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
