The Fosl1 Polyclonal Antibody (CAB5372) is a valuable tool for researchers studying Fos-like antigen 1 (Fosl1), a transcription factor that plays a key role in cell proliferation, differentiation, and transformation. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds to the Fosl1 protein, allowing for the detection and analysis of Fosl1 expression in a variety of cell types.Fosl1 is known to be involved in various biological processes, including cell cycle progression, apoptosis, and tumorigenesis.
Its dysregulation has been implicated in several types of cancer, making it a promising target for cancer research. By studying the expression and function of Fosl1 using this antibody, researchers can gain valuable insights into the mechanisms underlying tumor development and progression.Overall, the Fosl1 Polyclonal Antibody (CAB5372) offers researchers a reliable tool for investigating the role of Fosl1 in cancer and other diseases, ultimately contributing to the development of targeted therapies and personalized treatment options.
Product Name:
FOSL1 Rabbit Polyclonal Antibody
SKU:
CAB5372
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human FOSL1 (NP_005429.1).
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8061
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from C6 cells, using FOSL1 Rabbit pAb (CAB5372) at 1:1000 dilution.C6 cells were treated by PMA/TPA (200 nM) at 37℃ for 15 minutes after serum-starvation overnight.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
